I this article, Darius Rucker said he has received 5000 rejection letters in his life (estimate, of course).  "No" just means, go ask someone else.

Olga Solovei

I couldn't even venture a guess as to how many people have told me "no, no you aren't capable, good enough, have the skills, will ever be able to do that.  Even now, people I work with people who question me on ridiculous things.  Even when my resume reads like a novel and theirs is a sticky note.  Most of that is due to prejudice.  Me being "different".